Publications (41) BELÉN CLIMENT FLÓREZ publications

2023

  1. Sigma-1 receptor modulation fine-tunes KV1.5 channels and impacts pulmonary vascular function

    Pharmacological Research, Vol. 189

  2. The bitter taste receptor (TAS2R) agonist denatonium promotes a strong relaxation of rat corpus cavernosum

    Biochemical Pharmacology, Vol. 215

  3. The novel KV7 channel activator URO-K10 exerts enhanced pulmonary vascular effects independent of the KCNE4 regulatory subunit

    Biomedicine and Pharmacotherapy, Vol. 164

2022

  1. Cigarette smoke induces pulmonary arterial dysfunction through an imbalance in the redox status of the soluble guanylyl cyclase

    Free Radical Biology and Medicine, Vol. 193, pp. 9-22

  2. In vitro inhibition of phosphodiesterase type 4 enhances rat corpus cavernosum nerve-mediated relaxation induced by gasotransmitters

    Life Sciences, Vol. 296

2020

  1. Differential contribution of Nox1, Nox2 and Nox4 to kidney vascular oxidative stress and endothelial dysfunction in obesity

    Redox Biology, Vol. 28

  2. Effect of a novel pbl-traditional learning strategy on students' knowledge acquisition in pathophysiology. A pre-test and post-test study

    EDULEARN20 Proceedings: 12th International Conference on Education and New Learning Technologies (July 6th-7th, 2020, Online)

  3. Metabolic syndrome inhibits store-operated Ca2+ entry and calcium-induced calcium-release mechanism in coronary artery smooth muscle

    Biochemical Pharmacology, Vol. 182

2018

  1. Impaired Ca2+ handling in resistance arteries from genetically obese Zucker rats: Role of the PI3K, ERK1/2 and PKC signaling pathways

    Biochemical Pharmacology, Vol. 152, pp. 114-128

2017

  1. Underlying mechanisms preserving coronary basal tone and NO-mediated relaxation in obesity: Involvement of β1 subunit-mediated upregulation of BKCa channels

    Atherosclerosis, Vol. 263, pp. 227-236

2016

  1. Augmented oxidative stress and preserved vasoconstriction induced by hydrogen peroxide in coronary arteries in obesity: role of COX-2

    British Journal of Pharmacology, Vol. 173, Núm. 22, pp. 3176-3195

2015

  1. Hydrogen peroxide activates store-operated Ca2+ entry in coronary arteries

    British Journal of Pharmacology, Vol. 172, Núm. 22, pp. 5318-5332

  2. Tissue-specific up-regulation of arginase i and II induced by p38 MAPK mediates endothelial dysfunction in type 1 diabetes mellitus

    British Journal of Pharmacology, Vol. 172, Núm. 19, pp. 4684-4698

2014

  1. Effects of obesity on vascular potassium channels

    Current Vascular Pharmacology, Vol. 12, Núm. 3, pp. 438-452

  2. Upregulation of SK3 and IK1 channels contributes to the enhanced endothelial calcium signaling and the preserved coronary relaxation in obese Zucker rats

    PLoS ONE, Vol. 9, Núm. 10

2013

  1. Impaired endothelin calcium signaling coupled to endothelin type b receptors in penile arteries from insulin-resistant obese zucker rats

    Journal of Sexual Medicine, Vol. 10, Núm. 9, pp. 2141-2153

  2. Signaling pathways involved in the H2O2-induced vasoconstriction of rat coronary arteries

    Free Radical Biology and Medicine, Vol. 60, pp. 136-146

2012

  1. Large conductance Ca 2+-activated K + channels modulate endothelial cell outward currents and nitric oxide release in the intact rat superior mesenteric artery

    Biochemical and Biophysical Research Communications, Vol. 417, Núm. 3, pp. 1007-1013

  2. Role of neural no synthase (NNOS) uncoupling in the dysfunctional nitrergic vasorelaxation of penile arteries from insulin-resistant obese zucker rats

    PLoS ONE, Vol. 7, Núm. 4

2011

  1. Intact rat superior mesenteric artery endothelium is an electrical syncytium and expresses strong inward rectifier K+ conductance

    Biochemical and Biophysical Research Communications, Vol. 410, Núm. 3, pp. 501-507