Publicacions en col·laboració amb investigadors/es de Cardiff University (9)

2015

  1. The molecular and structural bases for the association of complement C3 mutations with atypical hemolytic uremic syndrome

    Molecular Immunology, Vol. 66, Núm. 2, pp. 263-273

2014

  1. A novel antibody against human factor B that blocks formation of the C3bB proconvertase and inhibits complement activation in disease models

    Journal of Immunology, Vol. 193, Núm. 11, pp. 5567-5575

2013

  1. C3 glomerulopathy-associated CFHR1 mutation alters FHR oligomerization and complement regulation

    Journal of Clinical Investigation, Vol. 123, Núm. 6, pp. 2434-2446

2012

  1. Complement dysregulation and disease: From genes and proteins to diagnostics and drugs

    Immunobiology, Vol. 217, Núm. 11, pp. 1034-1046

2010

  1. Human C3 mutation reveals a mechanism of dense deposit disease pathogenesis and provides insights into complement activation and regulation

    Journal of Clinical Investigation, Vol. 120, Núm. 10, pp. 3702-3712

  2. Variant-specific quantification of factor H in plasma identifies null alleles associated with atypical hemolytic uremic syndrome

    Kidney International, Vol. 78, Núm. 8, pp. 782-788

2009

  1. Functional basis of protection against age-related macular degeneration conferred by a common polymorphism in complement factor B

    Proceedings of the National Academy of Sciences of the United States of America, Vol. 106, Núm. 11, pp. 4366-4371

  2. The disease-protective complement factor H allotypic variant Ile62 shows increased binding affinity for C3b and enhanced cofactor activity

    Human Molecular Genetics, Vol. 18, Núm. 18, pp. 3452-3461

2008

  1. Measurement of factor H variants in plasma using variant-specific monoclonal antibodies: Application to assessing risk of age-related macular degeneration

    Investigative Ophthalmology and Visual Science, Vol. 49, Núm. 5, pp. 1983-1990