Publications in collaboration with researchers from Cardiff University (9)

2015

  1. The molecular and structural bases for the association of complement C3 mutations with atypical hemolytic uremic syndrome

    Molecular Immunology, Vol. 66, Núm. 2, pp. 263-273

2014

  1. A novel antibody against human factor B that blocks formation of the C3bB proconvertase and inhibits complement activation in disease models

    Journal of Immunology, Vol. 193, Núm. 11, pp. 5567-5575

2013

  1. C3 glomerulopathy-associated CFHR1 mutation alters FHR oligomerization and complement regulation

    Journal of Clinical Investigation, Vol. 123, Núm. 6, pp. 2434-2446

2012

  1. Complement dysregulation and disease: From genes and proteins to diagnostics and drugs

    Immunobiology, Vol. 217, Núm. 11, pp. 1034-1046

2010

  1. Human C3 mutation reveals a mechanism of dense deposit disease pathogenesis and provides insights into complement activation and regulation

    Journal of Clinical Investigation, Vol. 120, Núm. 10, pp. 3702-3712

  2. Variant-specific quantification of factor H in plasma identifies null alleles associated with atypical hemolytic uremic syndrome

    Kidney International, Vol. 78, Núm. 8, pp. 782-788

2009

  1. Functional basis of protection against age-related macular degeneration conferred by a common polymorphism in complement factor B

    Proceedings of the National Academy of Sciences of the United States of America, Vol. 106, Núm. 11, pp. 4366-4371

  2. The disease-protective complement factor H allotypic variant Ile62 shows increased binding affinity for C3b and enhanced cofactor activity

    Human Molecular Genetics, Vol. 18, Núm. 18, pp. 3452-3461

2008

  1. Measurement of factor H variants in plasma using variant-specific monoclonal antibodies: Application to assessing risk of age-related macular degeneration

    Investigative Ophthalmology and Visual Science, Vol. 49, Núm. 5, pp. 1983-1990