Farmacología y Toxicología
Departamento
Manuela
García López
Publicaciones en las que colabora con Manuela García López (43)
2020
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Na+ controls hypoxic signalling by the mitochondrial respiratory chain
Nature, Vol. 586, Núm. 7828, pp. 287-291
2016
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Melatonin protects against oxygen and glucose deprivation by decreasing extracellular glutamate and Nox-derived ROS in rat hippocampal slices
NeuroToxicology, Vol. 57, pp. 61-68
2015
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Both creatine and its product phosphocreatine reduce oxidative stress and afford neuroprotection in an in vitro Parkinson’s model
ASN Neuro, Vol. 6, Núm. 6
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Development of HuperTacrines as non-toxic, cholinesterase inhibitors for the potential treatment of Alzheimer’s disease
Mini-Reviews in Medicinal Chemistry, Vol. 15, Núm. 8, pp. 648-658
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Novel tacrine-grafted ugi adducts as multipotent anti-alzheimer drugs: A synthetic renewal in tacrine-ferulic acid hybrids
ChemMedChem, Vol. 10, Núm. 3, pp. 523-539
2014
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Dibenzo[1,4,5]thiadiazepine: A hardly-known heterocyclic system with neuroprotective properties of potential usefulness in the treatment of neurodegenerative diseases
European Journal of Medicinal Chemistry, Vol. 81, pp. 350-358
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ITH12410/SC058: A new neuroprotective compound with potential in the treatment of Alzheimer's disease
ACS Chemical Neuroscience, Vol. 5, Núm. 9, pp. 770-775
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Isoxazolotacrines as non-toxic and selective butyrylcholinesterase inhibitors for Alzheimer's disease
Future Medicinal Chemistry, Vol. 6, Núm. 17, pp. 1883-1891
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Neuroprotective effect of dimebon against ischemic neuronal damage
Neuroscience, Vol. 267, pp. 11-21
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Neuroprotective effect of melatonin against ischemia is partially mediated by alpha-7 nicotinic receptor modulation and HO-1 overexpression
Journal of Pineal Research, Vol. 56, Núm. 2, pp. 204-212
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New melatonin- N, N -dibenzyl(N -methyl)amine hybrids: Potent neurogenic agents with antioxidant, cholinergic, and neuroprotective properties as innovative drugs for alzheimers disease
Journal of Medicinal Chemistry, Vol. 57, Núm. 9, pp. 3773-3785
2013
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Enantioselective neuroprotective effects of tacripyrine ITH122 against oxygen and glucose deprivation in rat hippocampal slices
CNS Neuroscience and Therapeutics
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Novel multitarget ligand ITH33/IQM9.21 provides neuroprotection in in vitro and in vivo models related to brain ischemia
Neuropharmacology, Vol. 67, pp. 403-411
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PP2A ligand ITH12246 protects against memory impairment and focal cerebral ischemia in mice
ACS Chemical Neuroscience, Vol. 4, Núm. 9, pp. 1267-1277
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Protective effect of creatine against 6-hydroxydopamine-induced cell death in human neuroblastoma SH-SY5Y cells: Involvement of intracellular signaling pathways
Neuroscience, Vol. 238, pp. 185-194
2012
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Galantamine elicits neuroprotection by inhibiting iNOS, NADPH oxidase and ROS in hippocampal slices stressed with anoxia/reoxygenation
Neuropharmacology, Vol. 62, Núm. 2, pp. 1082-1090
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Guanosine protects human neuroblastoma SH-SY5Y cells against mitochondrial oxidative stress by inducing heme oxigenase-1 via PI3K/Akt/GSK-3β pathway
Neurochemistry International, Vol. 61, Núm. 3, pp. 397-404
2011
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Calcium signalling mediated through α7 and non-α7 nAChR stimulation is differentially regulated in bovine chromaffin cells to induce catecholamine release
British Journal of Pharmacology, Vol. 162, Núm. 1, pp. 94-110
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Cholinergic and neuroprotective drugs for the treatment of Alzheimer and neuronal vascular diseases. II. Synthesis, biological assessment, and molecular modelling of new tacrine analogues from highly substituted 2-aminopyridine-3- carbonitriles
Bioorganic and Medicinal Chemistry, Vol. 19, Núm. 1, pp. 122-133
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N-Acylaminophenothiazines: Neuroprotective agents displaying multifunctional activities for a potential treatment of Alzheimer's disease
European Journal of Medicinal Chemistry, Vol. 46, Núm. 6, pp. 2224-2235