Papel de los factores osteogénicos en el desarrollo de la rigidez arterial asociado a la enfermedad renal

  1. MANZANO LISTA, FRANCISCO JAVIER
Dirigida por:
  1. Miguel Angel Rubio Herrera Director
  2. María Soledad Fernández Alfonso Directora

Universidad de defensa: Universidad Complutense de Madrid

Fecha de defensa: 21 de junio de 2022

Tribunal:
  1. Olga Palomino Ruíz-Poveda Presidenta
  2. José Manuel Martínez Sesmero Secretario
  3. Concepción Fernández García Prieto Vocal
  4. Elena Vega Martin Vocal
  5. Gema Ruiz Hurtado Vocal

Tipo: Tesis

Resumen

Chronic kidney disease (CKD) is a progressive pathology with a high morbimortality and will soon become the fifth leading cause of death worldwide. This is due, among other causes, to the lack of early diagnostic markers that allow the identification and evaluation of incipient renal dysfunction, as well as early clinical intervention. As a result, the diagnosis of CKD occurs too late, when there is already an established renal damage that is difficult to reverse. This leads to significant cardiovascular (CV) mortality, a problem that is aggravated in diabetic patients. An important and often overlooked vascular complication of CKD is increased arterial stiffness, leading to various CV complications. Bone morphogenetic proteins (BMPs) are growth factors belonging to the TGF-β superfamily that are involved in a wide variety of processes, including bone formation...