Trastornos moleculares y genéticos en las glomerulopatías causadas por desregulación del complementocorrelaciones genotipo-fenotipo e implicaciones terapéuticas

  1. Caravaca Fontán, Fernando
Dirigida per:
  1. Elena Goicoechea de Jorge Directora
  2. Manuel Praga Terente Director

Universitat de defensa: Universidad Complutense de Madrid

Fecha de defensa: 11 de de novembre de 2020

Tribunal:
  1. José María Aguado García President
  2. Maria Angeles Goicoechea Diezhandino Secretària
  3. Mario Espinosa Hernandez Vocal
  4. Gabriel de Arriba de la Fuente Vocal
  5. Gema María Fernandez Juarez Vocal
Departament:
  1. Inmunología, Oftalmología y ORL

Tipus: Tesi

Teseo: 155159 DIALNET lock_openDocta Complutense editor

Resum

C3 glomerulopathy (C3G) is a clinicopathological entity secondary to the dysregulation of the alternative complement pathway in plasma and the glomerular microenvironment, and two different entities can be distinguished: C3 glomerulonephritis (C3GN) and dense deposit disease (DDD). The alternative complement dysregulation may be due to genetic abnormalities in complement genes and/or antibodies against complement components.Previous studies showed a therapeutic benefit of corticosteroids plusmycophenolate mofetil (MMF) in this entity, although the genetic and molecular profile of these patients were not systematically analyzed...