Trastornos moleculares y genéticos en las glomerulopatías causadas por desregulación del complementocorrelaciones genotipo-fenotipo e implicaciones terapéuticas

  1. Caravaca Fontán, Fernando
Dirigée par:
  1. Elena Goicoechea de Jorge Directrice
  2. Manuel Praga Terente Directeur

Université de défendre: Universidad Complutense de Madrid

Fecha de defensa: 11 novembre 2020

Jury:
  1. José María Aguado García President
  2. Maria Angeles Goicoechea Diezhandino Secrétaire
  3. Mario Espinosa Hernandez Rapporteur
  4. Gabriel de Arriba de la Fuente Rapporteur
  5. Gema María Fernandez Juarez Rapporteur
Département:
  1. Inmunología, Oftalmología y ORL

Type: Thèses

Teseo: 155159 DIALNET lock_openDocta Complutense editor

Résumé

C3 glomerulopathy (C3G) is a clinicopathological entity secondary to the dysregulation of the alternative complement pathway in plasma and the glomerular microenvironment, and two different entities can be distinguished: C3 glomerulonephritis (C3GN) and dense deposit disease (DDD). The alternative complement dysregulation may be due to genetic abnormalities in complement genes and/or antibodies against complement components.Previous studies showed a therapeutic benefit of corticosteroids plusmycophenolate mofetil (MMF) in this entity, although the genetic and molecular profile of these patients were not systematically analyzed...