Trastornos moleculares y genéticos en las glomerulopatías causadas por desregulación del complementocorrelaciones genotipo-fenotipo e implicaciones terapéuticas

  1. Caravaca Fontán, Fernando
unter der Leitung von:
  1. Elena Goicoechea de Jorge Doktormutter
  2. Manuel Praga Terente Doktorvater

Universität der Verteidigung: Universidad Complutense de Madrid

Fecha de defensa: 11 von November von 2020

Gericht:
  1. José María Aguado García Präsident
  2. Maria Angeles Goicoechea Diezhandino Sekretärin
  3. Mario Espinosa Hernandez Vocal
  4. Gabriel de Arriba de la Fuente Vocal
  5. Gema María Fernandez Juarez Vocal
Fachbereiche:
  1. Inmunología, Oftalmología y ORL

Art: Dissertation

Teseo: 155159 DIALNET lock_openDocta Complutense editor

Zusammenfassung

C3 glomerulopathy (C3G) is a clinicopathological entity secondary to the dysregulation of the alternative complement pathway in plasma and the glomerular microenvironment, and two different entities can be distinguished: C3 glomerulonephritis (C3GN) and dense deposit disease (DDD). The alternative complement dysregulation may be due to genetic abnormalities in complement genes and/or antibodies against complement components.Previous studies showed a therapeutic benefit of corticosteroids plusmycophenolate mofetil (MMF) in this entity, although the genetic and molecular profile of these patients were not systematically analyzed...