Trastornos moleculares y genéticos en las glomerulopatías causadas por desregulación del complementocorrelaciones genotipo-fenotipo e implicaciones terapéuticas

  1. Caravaca Fontán, Fernando
Zuzendaria:
  1. Elena Goicoechea de Jorge Zuzendaria
  2. Manuel Praga Terente Zuzendaria

Defentsa unibertsitatea: Universidad Complutense de Madrid

Fecha de defensa: 2020(e)ko azaroa-(a)k 11

Epaimahaia:
  1. José María Aguado García Presidentea
  2. Maria Angeles Goicoechea Diezhandino Idazkaria
  3. Mario Espinosa Hernandez Kidea
  4. Gabriel de Arriba de la Fuente Kidea
  5. Gema María Fernandez Juarez Kidea
Saila:
  1. Inmunología, Oftalmología y ORL

Mota: Tesia

Teseo: 155159 DIALNET lock_openDocta Complutense editor

Laburpena

C3 glomerulopathy (C3G) is a clinicopathological entity secondary to the dysregulation of the alternative complement pathway in plasma and the glomerular microenvironment, and two different entities can be distinguished: C3 glomerulonephritis (C3GN) and dense deposit disease (DDD). The alternative complement dysregulation may be due to genetic abnormalities in complement genes and/or antibodies against complement components.Previous studies showed a therapeutic benefit of corticosteroids plusmycophenolate mofetil (MMF) in this entity, although the genetic and molecular profile of these patients were not systematically analyzed...