Trastornos moleculares y genéticos en las glomerulopatías causadas por desregulación del complementocorrelaciones genotipo-fenotipo e implicaciones terapéuticas

  1. Caravaca Fontán, Fernando
Dirixida por:
  1. Elena Goicoechea de Jorge Director
  2. Manuel Praga Terente Director

Universidade de defensa: Universidad Complutense de Madrid

Fecha de defensa: 11 de novembro de 2020

Tribunal:
  1. José María Aguado García Presidente
  2. Maria Angeles Goicoechea Diezhandino Secretaria
  3. Mario Espinosa Hernandez Vogal
  4. Gabriel de Arriba de la Fuente Vogal
  5. Gema María Fernandez Juarez Vogal
Departamento:
  1. Inmunología, Oftalmología y ORL

Tipo: Tese

Teseo: 155159 DIALNET lock_openDocta Complutense editor

Resumo

C3 glomerulopathy (C3G) is a clinicopathological entity secondary to the dysregulation of the alternative complement pathway in plasma and the glomerular microenvironment, and two different entities can be distinguished: C3 glomerulonephritis (C3GN) and dense deposit disease (DDD). The alternative complement dysregulation may be due to genetic abnormalities in complement genes and/or antibodies against complement components.Previous studies showed a therapeutic benefit of corticosteroids plusmycophenolate mofetil (MMF) in this entity, although the genetic and molecular profile of these patients were not systematically analyzed...