Papel de p21/CDKN1A en la enfermedad hepática crónicaRole of p21/CDKN1A in chronic liver disease (CLD)
- Yulia Nevzorova Doktormutter
- Francisco Javier Cubero Palero Doktorvater
Universität der Verteidigung: Universidad Complutense de Madrid
Fecha de defensa: 06 von Juli von 2022
- Salvador Iborra Martín Präsident
- Ana Victoria Marín Marín Sekretärin
- Jordi García Vocal
- Gonzalo Jorquero Olave Vocal
- Rocío Gallego Durán Vocal
Art: Dissertation
Zusammenfassung
The increasing incidence of obesity and non-alcoholic fatty liver disease(NAFLD/NASH) currently represents a serious threat to global health, potentially leadingto an increase in the number of cases of advanced liver disease, cirrhosis and, ultimately,leading to hepatocellular carcinoma (HCC). The p21/CDKN1A gene is a cell cycleregulator that is involved in essential cellular processes such as: cell cycle arrest,apoptosis, differentiation, senescence, and DNA repair. The main aim of this study wasto evaluate the specific role of p21/CDKN1A in chronic liver disease (CLD)...