Papel de p21/CDKN1A en la enfermedad hepática crónicaRole of p21/CDKN1A in chronic liver disease (CLD)

  1. LAMAS PAZ, ARANTZA
Supervised by:
  1. Yulia Nevzorova Director
  2. Francisco Javier Cubero Palero Director

Defence university: Universidad Complutense de Madrid

Fecha de defensa: 06 July 2022

Committee:
  1. Salvador Iborra Martín Chair
  2. Ana Victoria Marín Marín Secretary
  3. Jordi García Committee member
  4. Gonzalo Jorquero Olave Committee member
  5. Rocío Gallego Durán Committee member

Type: Thesis

Teseo: 811014 DIALNET lock_openDocta Complutense editor

Abstract

The increasing incidence of obesity and non-alcoholic fatty liver disease(NAFLD/NASH) currently represents a serious threat to global health, potentially leadingto an increase in the number of cases of advanced liver disease, cirrhosis and, ultimately,leading to hepatocellular carcinoma (HCC). The p21/CDKN1A gene is a cell cycleregulator that is involved in essential cellular processes such as: cell cycle arrest,apoptosis, differentiation, senescence, and DNA repair. The main aim of this study wasto evaluate the specific role of p21/CDKN1A in chronic liver disease (CLD)...