Papel de p21/CDKN1A en la enfermedad hepática crónicaRole of p21/CDKN1A in chronic liver disease (CLD)

  1. LAMAS PAZ, ARANTZA
Dirigée par:
  1. Yulia Nevzorova Directrice
  2. Francisco Javier Cubero Palero Directeur

Université de défendre: Universidad Complutense de Madrid

Fecha de defensa: 06 juillet 2022

Jury:
  1. Salvador Iborra Martín President
  2. Ana Victoria Marín Marín Secrétaire
  3. Jordi García Rapporteur
  4. Gonzalo Jorquero Olave Rapporteur
  5. Rocío Gallego Durán Rapporteur

Type: Thèses

Teseo: 811014 DIALNET lock_openDocta Complutense editor

Résumé

The increasing incidence of obesity and non-alcoholic fatty liver disease(NAFLD/NASH) currently represents a serious threat to global health, potentially leadingto an increase in the number of cases of advanced liver disease, cirrhosis and, ultimately,leading to hepatocellular carcinoma (HCC). The p21/CDKN1A gene is a cell cycleregulator that is involved in essential cellular processes such as: cell cycle arrest,apoptosis, differentiation, senescence, and DNA repair. The main aim of this study wasto evaluate the specific role of p21/CDKN1A in chronic liver disease (CLD)...